Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology
Lingxuan Chen, Zoé Christenson Wick, Lauren M. Vetere, Nick D. Vaughan, Albert Jurkowski, Angelina Galas, Keziah S. Diego, Paul A. Philipsberg, Iván Soler, Yu Feng, Denise J. Cai, Tristan Shuman
The paper examines excitability changes in the medial entorhinal cortex of 3xTg mice at early and late stages of Alzheimer's disease pathology, finding hyperexcitability in specific cell types and altered synaptic ratios.
Journal of Neuroscience · Sep 15, 2023Peer-reviewedNeuroscience