Samantha Perez‐Miller

This study identifies interdomain interactions between the N-terminal and RNA binding domains of TDP-43 using NMR spectroscopy and computational modeling.

This study identifies polymodal gating mechanisms in the proton-activated chloride channel using pharmacological and computational approaches.

The paper identifies a unique NaV1.7 domain that can be targeted to produce analgesia by disrupting its interaction with CRMP2.

This study shows that SARS-CoV-2 Spike protein blocks VEGF-A/NRP-1 signaling, reducing pain and potentially contributing to asymptomatic transmission.

The paper identifies and validates small molecule and natural product inhibitors targeting the VEGF-A/NRP-1 interaction, with potential applications in treating neuropathic pain, cancer, and SARS-CoV-2 infection.

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.