STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
Hye‐Kyung Lee, Jichun Chen, Rachael Laura Philips, Sung‐Gwon Lee, Xingmin Feng, Zhijie Wu, Chengyu Liu, Aaron B. Schultz, Molly Dalzell, Manja Meggendorfer, Claudia Haferlach, Foster Birnbaum, Joel A Sexton, Amy E. Keating, John J. O’Shea, , Lothar G. Hennighausen
The paper investigates two STAT5B mutations in T cell leukemias, showing one causes gain-of-function and the other loss-of-function, with distinct impacts on immune cell populations and transcriptional activity.
Life Science Alliance · Apr 14, 2025Peer-reviewedGenetics