John J. O’Shea

Asymmetry and redundancy of STAT5 paralogs across CD8+ T cell differentiation states

The paper shows STAT5B is dominant and functionally distinct from STAT5A in CD8+ T cells, revealing redundancy and asymmetry in their roles during differentiation.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

The paper investigates two STAT5B mutations in T cell leukemias, showing one causes gain-of-function and the other loss-of-function, with distinct impacts on immune cell populations and transcriptional activity.

Human Germline Heterozygous Gain-of-Function STAT6 Variants Cause Severe Allergic Disease

This study identifies heterozygous gain-of-function STAT6 variants in two patients with severe allergic disease and shows JAK inhibitors reduce the enhanced STAT6 responses.