Subhash Chandra Mandal

Azadiradione regulates Heat Shock Factor 1 function by interacting with its DNA-binding domain independent of the oligomerization domain

This study shows azadiradione activates HSF1 by interacting with its DNA-binding domain, promoting oligomerization and HSE binding, independent of the oligomerization domain.

Polyphenol-rich fraction of Bergenia ligulata (Wall.) Engl. sensitizes colon and breast cancer metastasis in vivo: Evidence of cell-type specific mechanism

This study shows that PFBL from Bergenia ligulata reduces colon and breast cancer metastasis in mice through distinct mechanisms without harming healthy tissue.

HSF1 Activator Azadiradione Ameliorates Parkinson Disease and Extends Lifespan in Preclinical Models: Analysis of Underlying Molecular Mechanism

This study shows that azadiradione enhances protein quality control mechanisms and alleviates Parkinson's disease symptoms in preclinical models.

Ovine CD14- an immune response gene has a role against gastrointesinal nematode Haemonchus contortus -a novel report

The paper investigates the role of ovine CD14 in immune response against Haemonchus contortus, finding higher expression in infected sheep and evolutionary similarity to humans.

RIG-I has a role in immunity against Haemonchus contortus, a gastrointestinal parasite in Ovis aries- a novel report.

This paper identifies RIG-I's role in parasitic immunity against Haemonchus contortus in sheep through gene expression analysis and in silico studies.