Jayanta Mukhopadhyay

Human prion proteins and mutants through the lens of systems biology

The paper uses network analysis, MD simulations, and experiments to identify critical residues in human PrP that affect structural stability and misfolding.

Azadiradione regulates Heat Shock Factor 1 function by interacting with its DNA-binding domain independent of the oligomerization domain

This study shows azadiradione activates HSF1 by interacting with its DNA-binding domain, promoting oligomerization and HSE binding, independent of the oligomerization domain.

Epoxyazadiradione ameliorates Parkinson's disease by upregulating heat shock factor 1 and protein degradation pathways in mice.

This paper identifies Epoxyazadiradione as a compound that improves Parkinson's disease symptoms in mice by enhancing heat shock factor 1 and protein degradation pathways without affecting redox balance.