Mahadeb Pal

This study shows azadiradione activates HSF1 by interacting with its DNA-binding domain, promoting oligomerization and HSE binding, independent of the oligomerization domain.

This paper identifies Epoxyazadiradione as a compound that improves Parkinson's disease symptoms in mice by enhancing heat shock factor 1 and protein degradation pathways without affecting redox balance.

This study shows that PFBL from Bergenia ligulata reduces colon and breast cancer metastasis in mice through distinct mechanisms without harming healthy tissue.

This study shows that azadiradione enhances protein quality control mechanisms and alleviates Parkinson's disease symptoms in preclinical models.