Andrew H. Cooper

The paper demonstrates that precision targeting of injured sensory neurons using gene therapy alleviates neuropathic pain in mice.

The paper identifies cold-selective lamina I spinal projection neurons and their connections to brain regions involved in thermosensation.

This study shows that peripheral nerve injury preferentially eliminates specific DRG neuron subpopulations, particularly non-peptidergic nociceptors, and links this loss to neurotrophic support.

The paper uses single-nucleus RNA sequencing to identify five distinct classes of anterolateral system neurons in the adult mouse spinal cord and their laminar distribution.

This study shows that NPY-expressing inhibitory interneurons in the spinal dorsal horn reduce pain and itch behaviors, suggesting they are potential targets for treating pathological pain and itch.