Annemarie Lang

Automatic pain face analysis in mice: Applied to a varied dataset with non-standardized conditions

This paper introduces a deep learning model for automated pain face analysis in mice using the Mouse Grimace Scale, achieving high correlation with human raters and outperforming them in error magnitude.

Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche

This study shows that erythroid precursors in the bone marrow increase local oxygen levels after injury, promoting tissue repair by enhancing angiogenesis and osteogenesis.

YAP regulates periosteal expansion in fracture repair

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

Cyr61 delivery promotes angiogenesis during bone fracture repair

This study shows that Cyr61 delivery enhances angiogenesis during bone fracture repair, particularly in fractures with stable fixation, and may have therapeutic potential for poor vascularization.

YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulated bone development

This study shows YAP and TAZ regulate osteoblast precursor mobilization and angiogenesis during bone development, linking mechanical cues to vascular and bone formation.

Endothelial SMAD1/5 signaling couples angiogenesis to osteogenesis during long bone growth

Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint

This study combines bulk and single-cell RNA-seq to identify chondrocyte gene expression in murine knee joints, finding 75 overlapping genes related to cartilage homeostasis and osteoarthritis.