Author

Khaleda Afrin Bari

Western UniversityORCID 0000-0002-9087-2325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Patrick LajoieiD· 2 shared Christopher J. BrandliD· 1 shared Gabriela Nunes Marsiglio-LibraisiD· 1 shared Julie L. Genereaux· 1 shared Martin L. DuennwaldiD· 1 shared Matthew D. BergiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

Patrick LajoieORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 7, 2025

Adjusting extracellular pH restores proteostasis and extends lifespan in a yeast model of polyglutamine toxicity

Khaleda Afrin Bari, Gabriela Nunes Marsiglio-Librais, Martin L. Duennwald, Patrick Lajoie

The paper shows that adjusting extracellular pH to prevent acidification extends yeast lifespan by enhancing the heat shock response and promoting polyQ aggregation.

DOI 10.1101/2025.09.07.674719

yeastproteomics

GeneticsG3 Genes Genomes GeneticsPeer-reviewedOct 31, 2022

Tra1 controls the transcriptional landscape of the aging cell

Khaleda Afrin Bari, Matthew D. Berg, Julie L. Genereaux…·Patrick Lajoie

This study investigates the role of Tra1 in yeast chronological aging, finding it regulates stress response genes and mitochondrial function, impacting longevity.

4 citations

yeastbulk RNA-seq