Author

Gabriela Nunes Marsiglio-Librais

Western UniversityORCID 0000-0001-8119-8335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Patrick LajoieiD· 3 shared Rebecca S. ShapiroiD· 2 shared Bryan Lung· 1 shared Christopher J. BrandliD· 1 shared Iqra Razzaq· 1 shared Julie L. Genereaux· 1 shared Khaleda Afrin BariiD· 1 shared Martin L. DuennwaldiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

Patrick LajoieORCID

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3 papers

Recent·Most cited

Cell BiologyJournal of Cell SciencePeer-reviewedJun 17, 2026

Distinct Ire1-driven transcriptional responses control morphogenesis in Candida albicans

Samuel Stack-Couture, Gabriela Nunes Marsiglio-Librais, Bryan Lung…·Patrick Lajoie

This study identifies Ire1-driven transcriptional responses distinct from the canonical UPR in C. albicans, revealing HAC1-independent pathways and RIDD activity in morphogenesis.

1 citation

C. elegansbulk RNA-seq

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Cell BiologybioRxivPreprintSep 7, 2025

Adjusting extracellular pH restores proteostasis and extends lifespan in a yeast model of polyglutamine toxicity

Khaleda Afrin Bari, Gabriela Nunes Marsiglio-Librais, Martin L. Duennwald, Patrick Lajoie

The paper shows that adjusting extracellular pH to prevent acidification extends yeast lifespan by enhancing the heat shock response and promoting polyQ aggregation.

DOI 10.1101/2025.09.07.674719

yeastproteomics

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GeneticsG3 Genes Genomes GeneticsPeer-reviewedOct 27, 2023

Evolutionary diversity of the control of the azole response by Tra1 across yeast species

Gabriela Nunes Marsiglio-Librais, Yuwei Jiang, Iqra Razzaq…·Patrick Lajoie

The paper investigates how Tra1 regulates azole resistance in different yeast species, finding species-specific effects on gene expression and drug tolerance.

1 citation

C. elegansDNA methylation

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