Rishika Chowdary

This study identifies RAC1 as a druggable target in Shh-dependent medulloblastoma by showing its role in regulating GLI1 and GLI2 transcription and demonstrating the efficacy of the inhibitor GYS32661 in reducing tumor growth.

The paper integrates single-cell RNA sequencing data with drug response signatures to identify drug-sensitive and resistant glioblastoma cell states and predict synergistic drug combinations.

OrthologAL converts non-human transcriptomics data to human orthologs for drug discovery, preserving data structure and enabling use with human-annotated databases.

The paper identifies three single-cell vulnerability states in glioblastoma using transcriptomic data and CRISPR screens, showing differential drug sensitivity and spatial distribution.