Luz Clarita Ruiz

RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

This study identifies RAC1 as a druggable target in Shh-dependent medulloblastoma by showing its role in regulating GLI1 and GLI2 transcription and demonstrating the efficacy of the inhibitor GYS32661 in reducing tumor growth.

Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

The paper integrates single-cell RNA sequencing data with drug response signatures to identify drug-sensitive and resistant glioblastoma cell states and predict synergistic drug combinations.

In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients

This paper develops DrugSeq, a computational platform that predicts drug sensitivities in medulloblastoma subgroups, identifying subgroup-specific therapies and potential drug repositioning candidates.