Author

Madison L. Doolittle

Mayo ClinicORCID 0000-0003-0912-0095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David G. MonroeiD· 2 shared Dominik SauliD· 2 shared João F. PassosiD· 2 shared Nathan K. LeBrasseuriD· 2 shared Robyn Laura KosinskyiD· 2 shared Sundeep KhoslaiD· 2 shared Abhishek ChandraiD· 1 shared Ana Catarina FrancoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

David G. MonroeORCID

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3 papers

Recent·Most cited

Cell BiologyThe EMBO JournalPeer-reviewedOct 29, 2025

Distinct secretomes in p16- and p21- positive senescent cells across tissues

Dominik Saul, Diana Jurk, Madison L. Doolittle…·João F. Passos

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

93 citationstop 1%

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PhysiologyJournal of Clinical InvestigationPeer-reviewedMay 16, 2024

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

Dominik Saul, Madison L. Doolittle, Jennifer L. Rowsey…·Sundeep Khosla

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

46 citationstop 2%

mousebulk RNA-seq

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GeneticsPLoS GeneticsPeer-reviewedJun 4, 2020

Genetic Analysis of Osteoblast Activity Identifies Zbtb40 as a Regulator of Osteoblast Activity and Bone Mass

Madison L. Doolittle, Gina M. Calabrese, Larry D. Mesner…·Charles R. Farber

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

24 citations

mousestatistical model

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