Margherita Romeo

Modeling Immunoglobulin light chain amyloidosis in Caenorhabditis elegans

This study develops a C. elegans model expressing a human amyloidogenic light chain to study cardiac tropism in AL amyloidosis, finding pharyngeal impairment and oxidative stress similar to human cardiac disease.

Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects

This study investigates how curcumin's anti-aging effects are mediated through AhR-dependent and -independent pathways in different contexts.

Machine learning predicts immunoglobulin light chain toxicity through somatic mutations

This paper introduces LICTOR, a machine learning model that predicts immunoglobulin light chain toxicity in AL using somatic mutations, achieving 83% accuracy in predicting clinical phenotypes.

Role of misfolded tau in the onset and progression of brain toxicity after trauma

This study shows that misfolded tau from traumatic brain injury induces toxicity in C. elegans, suggesting it drives functional decline rather than just being a marker of neurodegeneration.