Shinsuke Niwa

Kif2C safeguards radial glial integrity to prevent cortical malformation

This study identifies Kif2C as a critical regulator of radial glial cell integrity, showing its role in preventing cortical malformations and linking its dysfunction to human neurodevelopmental disorders.

KLP-6 is a kinesin superfamily protein resistant to ADP inhibition

The paper identifies KLP-6 as a kinesin-3 resistant to ADP inhibition, showing its unique ATP selectivity through sequence and molecular dynamics analysis.

The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration

The paper shows UNC-83 isoforms differentially regulate kinesin-1 and dynein to control nuclear migration directionality during development.

Dimerization GAS2 mediates microtubule and F-actin crosslinking

This study presents cryo-EM structures of GAS2 domains bound to actin and microtubules, revealing their roles in cytoskeletal organization and dimerization.

Modular photostable fluorescent DNA blocks dissect the effects of pathogenic mutant kinesin on collective transport

The paper develops a photostable DNA block to study how a pathogenic kinesin mutant affects collective transport with wild-type kinesin, revealing velocity dynamics.

Processivity of the monomeric KLP-6 kinesin and a Brownian ratchet model with symmetric potentials

This study shows that the monomeric kinesin-3 motor KLP-6 moves processively along microtubules via its tail domain, explained by a Brownian ratchet model involving conformational changes rather than asymmetric potentials.

Kinesin family member Kif23 regulates cytokinetic division and maintains neural stem/progenitor cell pool in the developing neocortex

This study shows Kif23 is essential for proper cytokinesis and neural stem/progenitor cell maintenance in developing mouse and human neocortex, with its disruption leading to microcephaly-like phenotypes.