The paper systematically extracts and catalogs acylcarnitine metabolites from multiple repositories, identifying previously unknown carnitines and providing a resource for further metabolic research.

bioRxiv · Mar 31, 2026 · PreprintBioinformatics

Harmonization of IGF1 immunoassay methods using an LC-MS/MS method and associated normative dataset.

Eef G.W.M. Lentjes, Mark S. Pratt, Ido P. Kema, Martijn H. J. R. van Faassen, Ruben E.A. Musson, Michel J Vos

The paper generates and tests IGF1 reference materials for harmonizing immunoassay and LC-MS/MS methods and establishes age-related reference intervals using a biobank dataset.

bioRxiv · Feb 17, 2026 · PreprintBiochemistry

Community Curation of Microbial Metabolites Enables Biological Insights of Metabolomics Data

Helena Mannochio-Russo, Wilhan Donizete Gonçalves Nunes, Shipei Xing, Fernanda de Oliveira, Andrés Mauricio Caraballo‐Rodríguez, Paulo Wender Portal Gomes, Vincent Charron‐Lamoureux, Julius Agongo, Nicole E. Avalon, Tammy Bui, Lucia B. Cancelada, Marc G. Chevrette, Andrés Cumsille, Moysés de Araujo, Marilyn De Graeve, , Pieter C. Dorrestein

The paper introduces a collaborative platform for curating microbial metabolite knowledge to enhance metabolomics data interpretation.

bioRxiv · Jan 29, 2026 · PreprintBioinformatics

The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds

Helena Mannochio-Russo, Vincent Charron‐Lamoureux, Martijn H. J. R. van Faassen, Santosh Lamichhane, Wilhan Donizete Gonçalves Nunes, Victoria Deleray, Abubaker Patan, Kyle Vittali, Prajit Rajkumar, Yasin El Abiead, Haoqi Nina Zhao, Paulo Wender Portal Gomes, Ipsita Mohanty, Carlynda Lee, Aidan Sund, , Pieter C. Dorrestein

The paper creates a spectral library of N-acyl lipids from metabolomics data, identifies novel compounds, and links them to health conditions like HIV and cognitive impairment.

bioRxiv · Oct 31, 2024 · PreprintBioinformatics