Author

Sieglinde De Cae

Ghent UniversityORCID 0000-0002-9153-4926Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1

Frequent Co-Authors

Bert SchepensiD· 3 shared Xavier SaelensiD· 2 shared Alison V. TurneriD· 1 shared Alistair J. HenryiD· 1 shared Andrew G. Popplewell· 1 shared ANDREZA ESTEFANY DA SILVA OLIVEIRAiD· 1 shared Annelies Van HeckeiD· 1 shared Annette OhnemusiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

Bert SchepensORCID

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3 papers

Recent·Most cited

Revisiting Endothelial Tropism of SARS-CoV-2 Using a Cell-Specific hACE2 Mouse Model

Sahine Lameire, Nincy Debeuf, Julie Deckers, Caroline De Wolf, Manon Vanheerswynghels, Wendy Toussaint, Lize De Vlieger, Lien Van Hoecke, Sieglinde De Cae, Bert Schepens, Stijn Vanhee, Bart N. Lambrecht

This study uses a cell-specific hACE2 mouse model to investigate whether SARS-CoV-2 can directly infect endothelial cells, finding no evidence of productive infection or disease.

bioRxiv · May 1, 2025 · PreprintImmunology

Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein Expression

Ruben Almey, Kevin Mwangi, Sieglinde De Cae, Pathmanaban Ramasamy, Marijn Van Hulle, Ine Lentacker, Bert Schepens, Dieter L. D. Deforce, Geert Antoine Martens, Pieter Ramaut, Johannes P.C. Vissers, Xavier Saelens, Rein Verbeke, Maarten Dhaenens, Bart Van Puyvelde

The paper develops a targeted LC-MS method to quantify SARS-CoV-2 spike protein expression and enables proteome profiling of infected cells.

bioRxiv · Mar 11, 2025 · PreprintImmunology

Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents

Bert Schepens, Loes van Schie, Wim Nerinckx, Kenny Roose, Wander Van Breedam, Daria Fijałkowska, Simon Devos, Wannes Weyts, Sieglinde De Cae, Sandrine Vanmarcke, Chiara Lonigro, Hannah Eeckhaut, Dries Van Herpe, Jimmy Borloo, ANDREZA ESTEFANY DA SILVA OLIVEIRA, , Xavier Saelens

The paper describes the development of a broadly neutralizing antibody, XVR011, effective against SARS-CoV-2 and its variants in animal models.

bioRxiv · Mar 8, 2021 · PreprintMolecular Biology