Lien Van Hoecke

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

This study uses a cell-specific hACE2 mouse model to investigate whether SARS-CoV-2 can directly infect endothelial cells, finding no evidence of productive infection or disease.

This study identifies IL-34 as a novel factor enabling regulatory T cells to maintain brain barrier integrity during neuro-inflammation, with implications for treating neurological disorders.

The paper identifies a novel fibroblast subtype in the choroid plexus that forms a barrier between the choroid plexus stroma, brain, and cerebrospinal fluid.