Author

Karishma Valand

The Francis Crick InstituteORCID 0000-0002-9158-5782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Charles SwantoniD· 2 shared Julian DownwardiD· 2 shared A. J. Narvaez· 1 shared A. M. I. Le MaroisiD· 1 shared Alastair J. MagnessiD· 1 shared Andrea de CastroiD· 1 shared Asher MullokandoviD· 1 shared Chris MooreiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Charles SwantonORCID

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedNov 1, 2024

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

Megan Cole, Panayiotis Anastasiou, Claudia Lee…·Febe van Maldegem

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

33 citationstop 3%

mouseproteomics

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Cancer BiologybioRxivPreprintMay 14, 2024

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

A. M. I. Le Marois, Sasha Bailey, Steven Hooper…·Erik A. Sahai

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

3 citations

humanimaging

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