MicrobiologyCell Host & MicrobePeer-reviewed
Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases
Ilya А. Osterman, Bohdana Hurieva, Erez Yirmiya…·Rotem Sorek
The paper identifies a bacterial defense mechanism, aRES, that depletes NAD+ by producing ADPR-1P, which resists phage NARP1 reconstitution, and describes phage countermeasures including phosphatases and inhibitors.
DOI 10.1016/j.chom.2026.05.004