Jeremy Garb

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

The paper designs synthetic proteins that inhibit bacterial defense systems, enabling phage infection and plasmid transformation in otherwise resistant strains.

Functional diversity of phage sponge proteins that sequester host immune signals

The paper investigates the functional diversity of phage sponge proteins that sequester host immune signals, identifying new specificities against CBASS, Pycsar, and Thoeris systems.

Conserved catalytic activity of animal TIR domains functions in TLR4 signaling

This study shows that TIR domains in animals, including human TLR4, have conserved catalytic activity that produces cADPR and is essential for TLR4 signaling.

Structural modeling reveals viral proteins that manipulate host immune signaling

The paper identifies viral proteins that manipulate bacterial immune signaling by analyzing structural and biophysical traits, and develops a computational pipeline to predict such proteins in phage genomes.

The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products

This study shows that SARM1 TIR domains produce minor amounts of glycocyclic ADPR molecules in vitro and in bacterial cells, suggesting a potential role in axonal death.

Phages overcome bacterial immunity via diverse anti-defense proteins

This study identifies anti-defense proteins in phages that inhibit bacterial immune systems like Gabija, Thoeris, and Hachiman.