The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA
Swanand Hardikar, Ren Ren, Zhengzhou Ying, Jujun Zhou, John R. Horton, Matthew D. Bramble, Bin Liu, Yue Lu, Bigang Liu, Luis Della Coletta, Jianjun Shen, Jiameng Dan, Xing Zhang, Xiaodong Cheng, Taiping Chen
The paper identifies a unique DNA-binding domain in CDCA7 that recognizes a CpG dyad in non-B DNA, linking it to DNA methylation specificity in ICF syndrome.
Science Advances · Aug 23, 2024Peer-reviewedMolecular Biology