Taiping Chen

The paper identifies collateral sensitivity to MEK inhibition in MTAP-null NSCLC cells that develop resistance to PRMT5 inhibitors.

This paper determines the structure of HELLS in its autoinhibitory state and shows how CDCA7 and DNA activate it.

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

The paper identifies a unique DNA-binding domain in CDCA7 that recognizes a CpG dyad in non-B DNA, linking it to DNA methylation specificity in ICF syndrome.

The paper introduces ProTiler, a method to identify essential protein domains from CRISPR/Cas9 tiling-sgRNA screens, finding 175 CKHS regions with high overlap to annotated domains and novel unannotated domains.