Jesús F. San Miguel

Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma

This study uses single-cell multiomics to analyze CAR T cell dynamics in multiple myeloma, identifying regulatory mechanisms affecting persistence and dysfunction.

gMCStool: automated network-based tool to search for metabolic vulnerabilities in cancer

gMCStool identifies metabolic vulnerabilities in cancer by predicting synthetic lethal interactions using genome-scale metabolic networks and RNA-seq data.