Wei Xie

This study identifies ZW-2038, a hydroxypyridone-3-carboxamide analog, as an antiviral lead against orthopoxviruses with low micromolar potency and selectivity in human fibroblasts and organoid models.

This paper identifies and characterizes C10, a potent SARS-CoV-2 NSP14 inhibitor with antiviral activity and host transcriptome modulation effects.

The paper shows that unstructured mRNAs form RNA-RNA interactions to create TIS granule networks that assist protein folding and co-translational complex formation.

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.