Author

William A. Flavahan

University of Massachusetts Chan Medical SchoolORCID 0000-0002-9197-5764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Brendan A PachecoiD· 2 shared Kensei KishimotoiD· 2 shared Arthur M. MercurioiD· 1 shared Ayush KumariD· 1 shared Christi A. Wisniewski· 1 shared Hira Lal Goel· 1 shared Lihua Julie ZhuiD· 1 shared Rui LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Brendan A PachecoORCID

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2 papers

Recent·Most cited

High-coverage DNA sequence and modification profiling of targeted genomic elements using Nanopore-based Cas12a Targeted Ligation and Enrichment Sequencing (nCasTLES).

Samantha J. Vantine, Kensei Kishimoto, Brendan A Pacheco, William A. Flavahan

The paper introduces nCasTLES, a method for targeted sequencing using Cas12a to improve DNA sequence and modification profiling compared to nCATS.

bioRxiv · Aug 26, 2026 · PreprintMolecular Biology

Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism

Ayush Kumar, Kensei Kishimoto, Hira Lal Goel, Christi A. Wisniewski, Rui Li, Brendan A Pacheco, Lihua Julie Zhu, William A. Flavahan, Arthur M. Mercurio

This study shows that radiation resistance in TNBC enhances metastasis through RNA metabolism changes, specifically via HNRNPL-mediated circRNAs that regulate ITGβ3 expression.

Science Advances · Oct 17, 2025Peer-reviewedCancer Biology