Arthur M. Mercurio

This study identifies a STAT3/LATS1 signaling axis mediated by folate receptor α that enables breast cancer cells to resist ferroptotic stress from ECM detachment and IKE treatment.

This study identifies folate receptor α as a key contributor to radiation resistance in neuroendocrine prostate cancer by maintaining redox homeostasis through the folate-FR axis.

This study delivers IRS2-targeting siRNAs to mammary tumors via albumin-binding dendrimers, reducing tumor growth by inhibiting Irs2 expression and altering tumor microenvironment features.

This study shows that radiation resistance in TNBC enhances metastasis through RNA metabolism changes, specifically via HNRNPL-mediated circRNAs that regulate ITGβ3 expression.

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.