Author

Hira Lal Goel

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Arthur M. MercurioiD· 3 shared Ayush KumariD· 2 shared Boris S. Dimitrov· 2 shared Christi A. Silva· 2 shared Lihua Julie ZhuiD· 2 shared Brendan A PachecoiD· 1 shared Christi A. Wisniewski· 1 shared Emma MohlmanniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

Arthur M. MercurioORCID

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4 papers

Recent·Most cited

Activation of a STAT3/LATS1 Signaling Axis by Folate Receptor α Enables Breast Cancer Cells to Resist Physiological Ferroptotic Stress

Prajakta Prasad Ambegaokar, Hira Lal Goel, Emmet R. Karner, Boris S. Dimitrov, Christi A. Silva, Arthur M. Mercurio

This study identifies a STAT3/LATS1 signaling axis mediated by folate receptor α that enables breast cancer cells to resist ferroptotic stress from ECM detachment and IKE treatment.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in PIK3CA mutant breast cancer

Michael W. Lero, Jennifer S. Morgan, Michael-Anthony Card, Lihua Julie Zhu, Junhui Li, Rui Li, Quyen Thu Bui, Emma Mohlmann, Hira Lal Goel, Leslie M. J. Shaw

This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.

Journal of Biological Chemistry · Aug 10, 2026Peer-reviewedCancer Biology

Folate Receptor α Contributes to Radiation Resistance in Neuroendocrine Prostate Cancer by Regulating Redox Homeostasis

Hira Lal Goel, Tao Wang, Boris S. Dimitrov, Ayush Kumar, Christi A. Silva, Thomas J. FitzGerald, Arthur M. Mercurio

This study identifies folate receptor α as a key contributor to radiation resistance in neuroendocrine prostate cancer by maintaining redox homeostasis through the folate-FR axis.

bioRxiv · Mar 30, 2026 · PreprintCancer Biology

Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism

Ayush Kumar, Kensei Kishimoto, Hira Lal Goel, Christi A. Wisniewski, Rui Li, Brendan A Pacheco, Lihua Julie Zhu, William A. Flavahan, Arthur M. Mercurio

This study shows that radiation resistance in TNBC enhances metastasis through RNA metabolism changes, specifically via HNRNPL-mediated circRNAs that regulate ITGβ3 expression.

Science Advances · Oct 17, 2025Peer-reviewedCancer Biology