Calcium (Ca2+) fluxes at Mitochondria-ER Contact Sites (MERCS) are a new target of senolysis in Therapy-Induced Senescence (TIS).
Andrea Puebla-Huerta, Hernán Huerta, Camila Quezada-Gutiérrez, Pablo Morgado-Cáceres, César Casanova-Canelo, Sandra Aurora Niño, Sergio Linsambarth, Osmán Díaz-Rivera, Jose Alberto Lopez-Dominguez, Sandra Rodríguez-López, José Antonio González-Reyes, Galdo Bustos, Eduardo Silva-Pavez, Alenka Lovy, Gabriel Quiroz, , César Cárdenas
This study shows that inhibiting ER-mitochondria Ca2+ flux is a new target for senolysis in therapy-induced senescence.
npj Aging · Feb 21, 2025Peer-reviewedCell Biology