Inhibition of the metalloprotease ADAM19 as a Novel Senomorphic Strategy to Ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)
Sudipta Bar, Tyler A. U. Hilsabeck, Blaine Pattavina, Jose Alberto Lopez-Dominguez, Nathan Basisty, Joanna Bons, Mark A. Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi, Amit Sharma
This study identifies ADAM19 as a modulator of the senescence-associated secretory phenotype (SASP) and shows that its inhibition reduces gut permeability and senescence markers in multiple species.
Aging · Mar 20, 2025Peer-reviewedMolecular Biology