Ricardo Costeira

methbiome: reference-based DNA methylation profiling of long-read metagenomic data

The paper introduces methbiome, a tool for reference-based DNA methylation profiling of long-read metagenomic data, enabling cross-platform and between-sample comparison of methylation signals in microbiomes.

Theobromine is Associated with Slower Epigenetic Ageing

The paper finds that higher serum theobromine levels are associated with slower epigenetic ageing in humans, as measured by GrimAge and DNAmTL.

DNA methylation and gene expression trajectories of human postprandial metabolism

The paper identifies DNA methylation and gene expression changes in human blood after a meal, linking them to cardiometabolic health and obesity-related genes.

Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis

This study investigates how hemin availability affects DNA methylation and gene expression in Porphyromonas gingivalis, identifying coordinated changes in six genes related to virulence.

Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans

This study shows that age-related skewed X chromosome inactivation in females is linked to increased cardiovascular disease risk and cancer incidence.

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

This study identifies DNA methylation sites associated with coffee and tea consumption using EWAS, finding potential links to fatty liver disease through PHGDH expression.