Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease
Mohini Mendiratta, Meenakshi Mendiratta, Shuvadeep Ganguly, Sandeep Rai, Ritu Gupta, Lalit Kumar, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Prabhat Singh Malik, Raja Pramanik, Mukul Aggarwal, Aditya Gupta, Rishi Dhawan, Tulika Seth, , Ranjit Kumar Sahoo
This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.
Stem Cell Research & Therapy · Oct 29, 2024Peer-reviewedImmunology