Gary J. Schwartz

NgBR controls hepatic adiponectin signaling competence through KAT7-dependent chromatin regulation

This study identifies NgBR as a regulator of hepatic adiponectin sensitivity, showing that it maintains adiponectin receptor competence through KAT7-dependent chromatin regulation.

Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue

This study identifies Slit3 fragments that coordinate neurovascular expansion and thermogenesis in brown adipose tissue by regulating angiogenesis and sympathetic innervation.

A novel subset of hepatocytes is simultaneously gluconeogenic and de novo lipogenic in the fed state and is naturally insulin resistant

Liver-innervating vagal sensory neurons play an indispensable role in the development of hepatic steatosis and anxiety-like behavior in mice fed a high-fat diet.

This study shows that liver-innervating vagal sensory neurons contribute to hepatic steatosis and anxiety-like behavior in mice on a high-fat diet, and their removal prevents obesity and improves metabolic outcomes.

Development of novel tools for dissection of central versus peripheral dopamine D2-like receptor signaling in dysglycemia

The paper develops pharmacological tools to selectively target central versus peripheral dopamine D2-like receptors and shows their distinct roles in treating dysglycemia.

DISRUPTION OF SYMPATHETIC OUTFLOW TO INTRA-ABDOMINAL ORGANS EMULATES THE METABOLIC EFFECTS OF SLEEVE GASTRECTOMY IN OBESE MICE

This study shows that sleeve gastrectomy (SG) causes degeneration of sympathetic neurons in the celiac-superior mesenteric ganglia (CSMG), which mediates metabolic effects like weight loss and glycemic improvement.

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

This study shows mTORC1 in AGRP neurons integrates food-related cues to control iBAT thermogenesis in mice, linking energy availability to adaptive energy expenditure.