This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.

bioRxiv · Nov 2, 2026 · PreprintCell Biology

NAD+ precursor treatment prevents cardiomyopathybut disrupts erythroid maturation in mitochondrial progeria

Nahid Akthar Khan, Kati J. Ahlqvist, Swagat Pradhan, Juan C. Landoni, Christopher Benjamin Jackson, Aleksandra Zhaivoron, Riikka Kivelä, Liliya Euro, Anu Suomalainen

This study shows that NAD+ precursor treatment improves cardiac function but worsens erythroid maturation in mitochondrial progeria, highlighting tissue-specific effects of NAD+ boosting.

Cell Reports · Aug 29, 2026Peer-reviewedPhysiology

Dynamics of blood NAD and glutathione in health, disease, aging and under NAD-booster treatment

Liliya Euro, Kimmo Haimilahti, Sonja Jansson, Saara Forsström, Jana Buzková, Anu Suomalainen

The paper measures NAD and glutathione levels in blood across health, disease, aging, and NAD-boosting treatment, finding age-independent normal distributions and disease-specific redox fingerprints.

Redox Biology · Aug 17, 2026Peer-reviewedPharmacology & Toxicology

Preferential binding of ADP-bound mitochondrial HSP70 to the nucleotide exchange factor GRPEL1 over GRPEL2

Pooja Manjunath, Gorazd Stojkovič, Liliya Euro, Svetlana A. Konovalova, Sjoerd Wanrooij, M. Kristian Koski, Henna Tyynismaa

This study shows ADP-bound mtHSP70 binds preferentially to GRPEL1 over GRPEL2, with structural insights into their functional differences.

Protein Science · Oct 24, 2024Peer-reviewedBiochemistry

Twinkle is not the mitochondrial DNA replicative helicase in C. elegans, but may have alternate mitochondrial functions

Hope R. Henderson, Liliya Euro, Anu Suomalainen, Andrew G. Dillin

This study shows that twnk-1 in C. elegans is not the mitochondrial DNA replicative helicase, but instead has alternative mitochondrial functions.

bioRxiv · Feb 20, 2019 · PreprintMolecular Biology