Author

Nathan C. Boles

Neural Stem Cell InstituteORCID 0000-0002-9253-9411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Sally TempleiD· 3 shared Farhad FarjoodiD· 2 shared Steven Lotz· 2 shared Susan K. Goderie· 2 shared Taylor B. BertucciiD· 2 shared Alison GoateiD· 1 shared Brigitte L. ArduiniiD· 1 shared Celeste M M. KarchiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Sally TempleORCID

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3 papers

Recent·Most cited

Single Cell Transcriptomics and Surface Protein Expression Reveal Distinct Cellular and Molecular Phenotypes in Human RPESC-RPE and PSC-RPE

Swapna Nandakumar, Farhad Farjood, Taylor B. Bertucci, Steven Lotz, Skanda Sai, Yue Wang, Jade A. Kozak, Brigitte L. Arduini, Jeffrey H. Stern, Nathan C. Boles, Sally Temple

The paper compares single-cell transcriptomic and surface protein profiles of RPESC-RPE and PSC-RPE, finding differences in gene expression and surface markers that suggest functional and immunomodulatory differences.

bioRxiv · Mar 1, 2026 · PreprintCell Biology

Adult Mouse Leptomeninges Exhibit Regional and Age-related Cellular Heterogeneity and Gene Expression Differences Implicating Mental Disorders

Christina A. Allen, Susan K. Goderie, Mo Liu, Thomas R. Kiehl, Farhad Farjood, Yue Wang, Nathan C. Boles, Sally Temple

The paper analyzes regional and age-related differences in adult mouse leptomeninges using snucRNA-seq, revealing gene expression patterns linked to mental disorders.

bioRxiv · Sep 10, 2023 · PreprintNeuroscience

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

Kathryn R. Bowles, M. Catarina Silva, Kristen R. Whitney, Taylor B. Bertucci, Jacob C. Garza, Nathan C. Boles, Kevin H. Strang, Sidhartha K. Mahali, Jacob A. Marsh, Cynthia Chen, Derian A. Pugh, Yiyuan Liu, Joshua E. Berlind, Jesse D. Lai, Susan K. Goderie, , Sally Temple

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.

bioRxiv · Feb 3, 2021 · PreprintNeuroscience