Author

Hiroshi Kuba

Nagoya UniversityORCID 0000-0002-9256-2726Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Ryo EgawaiD· 2 shared Ryota FukayaiD· 2 shared Akinori Takase· 1 shared Ayato SatoiD· 1 shared Chisa OkadaiD· 1 shared Dai WatanabeiD· 1 shared Daisuke MoriiD· 1 shared Geyao DongiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersNeuroscience

Ryo EgawaORCID

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4 papers

Recent·Most cited

CRISPR/Cas9-based knockout screening revealed GSK3β as a regulator of axon initial segment structural plasticity

Yixuan Du, Ryo Egawa, Ryota Adachi, Kenta Motohara, Kazuki Furumichi, Ryota Fukaya, Hesheng Chen, Hiroshi Kuba

The paper uses CRISPR/Cas9 knockout screening in chick embryos to identify GSK3β as a regulator of axon initial segment structural plasticity during development.

bioRxiv · Jun 25, 2026 · PreprintNeuroscience

Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

Ryo Egawa, Kota Hiraga, Ryosuke Matsui, Dai Watanabe, Hiroshi Kuba

The paper investigates how regional differences in oligodendrocyte properties influence Ranvier node spacing in axons involved in sound localization.

eLife · Dec 23, 2025Peer-reviewedNeuroscience

Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development

Geyao Dong, Daisuke Mori, Tetsuo Matsuzaki, Rinako Tanaka, Norimichi Itoh, Takaaki Matsui, Ayato Sato, Yuko Arioka, Hiroki Okumura, Ryota Fukaya, Hiroshi Kuba, Taku Nagai, Toshitaka Nabeshima, Hiroaki Ikesue, Takao Kohno, , Kiyofumi Yamada

This study identifies Twinfilin-1 phosphorylation as a key component of reelin signaling that regulates actin dynamics and spine development in neurons.

Pharmacological Research · Oct 10, 2025Peer-reviewedNeuroscience

Activity-regulated micro-exon splicing programs underlie late-onset plasticity at the axon initial segment

Mohamed Darwish, Satoko Suzuki, Yuki Ogawa, Akinori Takase, Masami Tanaka, Yoko Iijima, Yuji Sato, Mariko Suzuki, Yumi Kanegae, Chisa Okada, Masayuki Takana, Hirotaka James Okano, Hiroshi Kuba, Takatoshi Iijima

The paper identifies micro-exon splicing changes in AIS proteins as a mechanism for activity-regulated late-onset plasticity in cerebellar granule cells.

bioRxiv · Oct 29, 2023 · PreprintNeuroscience