Synchronized beta cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo
Melissa T. Adams, Christopher A. Reissaus, JaeAnn M. Dwulet, Erli Jin, Joseph M. Szulczewski, Melissa R. Lyman, Sophia M. Sdao, Sutichot D. Nimkulrat, Suzanne M. Ponik, Matthew J. Merrins, Richard K.P. Benninger, Raghavendra G. Mirmira, Amelia K. Linnemann, Barak Blum
This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.
bioRxiv · Dec 11, 2019 · PreprintDevelopmental Biology