Melissa R. Lyman

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

The paper introduces a framework for mathematical modeling of multicellular systems using interpretable cell behavior rules derived from biological knowledge and multi-omics data.

Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

Synchronized beta cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo

This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.