Matthew J. Merrins

The paper develops and validates a genetically encoded fluorescent sensor, iG6PSnFR, for measuring glucose-6-phosphate dynamics across multiple biological contexts.

The paper shows primary cilia use localized glycolysis and mitochondrial PEP to generate ATP, and can access ATP from the cell body when glucose is limited.

CRISP improves cell segmentation accuracy in dense calcium imaging data by refining user-drawn masks and automatically identifying cell outlines.

This study shows that the α-cell mitochondrial PEP cycle senses amino acids and regulates Ca2+ levels without affecting glucagon secretion.

This paper uses 3D light-sheet imaging to study β-cell subpopulations and their role in islet Ca2+ oscillations, finding that glucokinase activity patterns leader cells at the periphery.

This study shows leucine suppresses glucagon secretion from pancreatic islets by reducing cAMP, with effects dependent on mitochondrial anaplerosis via glutamate dehydrogenase.

This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.