Doxycycline inhibits both apicoplast and mitochondrial translation in apicomplexan parasites
Michaela S. Bulloch, Emily M. Crisafulli, Jenni A. Hayward, Saishyam Ramesh, Andrew E. Maclean, Linden Muellner-Wong, Shuai Nie, David A. Stroud, Lilach Sheiner, Alexander G. Maier, Giel G. van Dooren, Stuart A. Ralph
This study shows doxycycline inhibits apicoplast and mitochondrial translation in Plasmodium falciparum and Toxoplasma gondii, reducing protein abundance and mitochondrial complex IV activity.
bioRxiv · Jun 7, 2026 · PreprintMicrobiology