Stuart A. Ralph

This study shows doxycycline inhibits apicoplast and mitochondrial translation in Plasmodium falciparum and Toxoplasma gondii, reducing protein abundance and mitochondrial complex IV activity.

The paper investigates m6A methylation in Plasmodium falciparum, showing its role in polyadenylation and transcription termination.

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

This study shows that apicoplast-derived isoprenoids are essential for GPI anchor biosynthesis in Plasmodium falciparum, which is critical for parasite egress and invasion.

This study uses direct nanopore sequencing to analyze alternative splicing in apicomplexan parasites, finding widespread intron retention and premature stop codons, suggesting alternative splicing contributes to transcriptomic diversity.