Rare centenarian SIRT6 coding variants elevate SIRT6 protein levels and resist cellular senescence
Jiping Yang, HyeRim Han, Xifan Wang, Yizhou Zhu, Haiqi Chen, Yousin Suh
The paper identifies rare SIRT6 variants in centenarians that increase protein levels and delay cellular senescence, offering insights for geroprotective therapies.
bioRxiv · Sep 29, 2025 · PreprintCell Biology