HyeRim Han

This study identifies UBE3C as a longevity-associated E3 ligase that maintains nuclear lamina integrity by modulating LMNB1 and LBR through selective autophagy, delaying senescence.

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

The paper identifies cis-regulatory elements controlling cellular senescence by performing CRISPR screens in human mesenchymal stromal cells, revealing a primate-specific SINE element that modulates P16INK4a and P15INK4b.

The paper identifies rare SIRT6 variants in centenarians that increase protein levels and delay cellular senescence, offering insights for geroprotective therapies.

The paper investigates how multiple FGFR1 mutations affect tumorigenic mechanisms in glioneuronal tumors by analyzing their interactomes and functional impacts.