Jiping Yang

This study identifies UBE3C as a longevity-associated E3 ligase that maintains nuclear lamina integrity by modulating LMNB1 and LBR through selective autophagy, delaying senescence.

The paper identifies functional non-coding variants affecting Alzheimer's disease risk using MPRA and validates their effects through CRISPR/Cas9.

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

The paper identifies cis-regulatory elements controlling cellular senescence by performing CRISPR screens in human mesenchymal stromal cells, revealing a primate-specific SINE element that modulates P16INK4a and P15INK4b.

The paper identifies rare SIRT6 variants in centenarians that increase protein levels and delay cellular senescence, offering insights for geroprotective therapies.

This study uses single-cell transcriptomics to analyze mouse ovarian aging and identifies molecular changes associated with the estropausal transition.

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.

This study identifies miR-142-3p as a regulator of human longevity by modulating the insulin/IGF-1 signaling pathway in B-cells and mice.

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.