The paper investigates DNA methylation and transcriptomic changes in chronic demyelinated MS lesions, showing hypermethylation of myelination-related genes and demonstrating reversible effects through epigenetic editing.

Acta Neuropathologica · Jun 7, 2023Peer-reviewedNeuroscience

Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease

Joanne Trinh, Andrew A. Hicks, Inke Regina König, Sylvie Delcambre, Theresa Lüth, Susen Schaake, Kobi Wasner, Jenny Ghelfi, Max Borsche, Carles Vilariño‐Güell, Fayçel Hentati, Elisabeth Luisa Germer, Peter Bauer, Masashi Takanashi, Vladimir Kostić, , Anne Grünewald

The paper identifies mitochondrial DNA heteroplasmy as a marker distinguishing disease manifestation in PINK1/PRKN mutation carriers.

Brain · Dec 7, 2022Peer-reviewedGenetic & Genomic Medicine

Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner

Jake Vorbach Aronowitz, Alice Perez, Christopher OʼBrien, Siaresh Aziz, Erica Rodriguez, Kobi Wasner, Sissi Palma Ribeiro, Dovounnae Green, Farhana Faruk, Carolyn L. Pytte

This study shows that altering song structure through unilateral vocal nerve resection affects neurogenesis in specific brain regions of songbirds, with no impact on HVC but reduced neurons in NCM and Area X.

PLoS ONE · Aug 31, 2021Peer-reviewedNeuroscience