Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutations
Guoming Ma, Congcong Xia, Boyu Lyu, Jie Liu, Fang Luo, Mingfeng Guan, Junying Wang, Li Sun, Lin Zhang, Yan Chen, Yingwei Mao, Guoqiang Yu, Wenyuan Wang
This study profiles temporal RNA-seq in iPSC-derived motor neurons from ALS patients with specific mutations, identifying shared gene expression and splicing defects across different mutations.
bioRxiv · Oct 15, 2024 · PreprintNeuroscience