Debbie I. McKenzie

Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging

This study uses nanopore sequencing to show that mtDNA deletion mutations increase exponentially with age and map to a wider genomic region, with novel algorithms improving detection accuracy.

Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats

This study investigates the effects of remdesivir on mitochondrial DNA in aged rats and finds no significant changes in copy number or deletion mutation frequency.

Transmission of Cervid Prions to Humanized Mice Demonstrates the Zoonotic Potential of CWD

This study shows CWD prions can infect humanized mice, leading to atypical symptoms and transmissible infectivity, suggesting zoonotic potential and possible human transmission.