Jonathan Wanagat

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

This study shows that unacylated ghrelin prevents muscle and mitochondrial dysfunction in cancer cachexia by improving muscle mass, mitochondrial function, and reducing proteolysis.

This study uses nanopore sequencing to show that mtDNA deletion mutations increase exponentially with age and map to a wider genomic region, with novel algorithms improving detection accuracy.

This study investigates the effects of remdesivir on mitochondrial DNA in aged rats and finds no significant changes in copy number or deletion mutation frequency.

This paper introduces a method to sequence mtDNA using Cas9-guided adaptor ligation and nanopore long reads, enabling mutation phasing and detection of age-induced deletions in a patient with mtDNA-linked syndrome.