Author

Amy R. Vandiver

University of California, Los AngelesORCID 0000-0003-2176-9161Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:variant calling· 2 Assay:long-read sequencing· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jonathan WanagatiD· 3 shared Austin N. HoangiD· 2 shared Winston TimpiD· 2 shared Allen J. HerbstiD· 1 shared Bérénice Anath BenayouniD· 1 shared Bert M. VerheijeniD· 1 shared Brittany PielstickiD· 1 shared Cathy C. LeeiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenomics

Jonathan WanagatORCID

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3 papers

Recent·Most cited

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

Sarah J. Shemtov, Eric Hwang, Claire S Chung, Herbert Anson, Lucy Carrillo, Sangmin Lee, Ivetta Vorobyova, 万俊香, Scott R. Kennedy, Amy R. Vandiver, Bert M. Verheijen, Whitaker Cohn, Bérénice Anath Benayoun, Max Andrew Thorwald, Pinchas Cohen, , Marc Vermulst

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

bioRxiv · Sep 27, 2026 · PreprintGenetics

Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging

Amy R. Vandiver, Austin N. Hoang, Allen J. Herbst, Cathy C. Lee, Judd M. Aiken, Debbie I. McKenzie, Michael A. Teitell, Winston Timp, Jonathan Wanagat

This study uses nanopore sequencing to show that mtDNA deletion mutations increase exponentially with age and map to a wider genomic region, with novel algorithms improving detection accuracy.

Aging Cell · May 3, 2023Peer-reviewedGenomics

Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation

Amy R. Vandiver, Brittany Pielstick, Timothy Gilpatrick, Austin N. Hoang, Hillary J. Vernon, Jonathan Wanagat, Winston Timp

This paper introduces a method to sequence mtDNA using Cas9-guided adaptor ligation and nanopore long reads, enabling mutation phasing and detection of age-induced deletions in a patient with mtDNA-linked syndrome.

Mitochondrion · Jul 1, 2022Peer-reviewedGenomics